A friend shared this and I found it an interesting read. It is a different take on COVID-19 based off a supercomputer study done on the genetic composition. Hoping to get some feedback on the study from doctors, see what they say about it.
Tag: CCPCoV
Some Interesting Reads
On COVID19 and treatment, this study looks at T-cell reactions that provide a possible immunity, or at least a body primed to fight off COVID19, based off previous T-cell reactions to colds, which share some of the COVID genome. By testing blood samples taken well before the spread of COVID-19/SARS-COV-2, it would appear that some people do indeed have T-cells already primed to go after the disease. Interesting.
This article and this article by Molly Hemingway are well worth a read. One deals with the media and it’s coverage of the spymaster story and it’s crumbling. The other deals with the disturbing (though far from new) efforts and willingness to falsify history for political gain.
COVID-19 17Apr20
Beyond the guidelines on ending this flippin lockdown, there is a fair bit of news and even some good news. Let’s start with the good news.
First, the clinical trial of Remdesivir, from Gilead, has proven successful. You can read more here.
Second, a trial of Pluristem Theraputics, Inc.’s allogenic placental expanded (PLX) cells is now underway in the U.S. Seven patients at high risk of death in Israel were treated with it, and all survived. It is worth noting that the treatment may suppress or reverse the over-activation of the immune system that appears to be the cause of death in a number of victims.
While the study is from China (trust nothing, verify the everliving out of it), it is safe to go outside and stay there. You are far more likely to get it, and for multiple infections to occur if you are inside. I will echo a number of others who said ‘No duh, closing parks, beaches, etc. was fracking stupid’ and I will add that it was done by power hungry fascists who need to be removed from office ASAP.
In potentially good news, the CDC is looking at the universal testing results from a men’s shelter in Boston. A small number of positives led to the decision to do a universal test, which resulted in 146 of 397 people tested being confirmed as infected — and none of the 146 were symptomatic. Seriously, go read this as it turns a lot of the CDC/NIAIC/Etc. assumptions on their head. False assumptions lead to bad guidelines and operations. Correcting that is imperative, for both biomedical and political reasons.
In more neutral news, it appears that obesity may significantly increase your chance of becoming severely ill with COVID-19, particularly in younger to middle-aged people. I will be interested in watching to see what linkage this has with the reports that glucose metabolism (and diabetes) may play an important part in that over-stimulation of the immune system (cytokine storms) mentioned earlier. Certain types of diabetes are often linked to obesity. If COVID-19 and certain flus are indeed causing deaths by cytokine storms, understanding the mechanism is crucial to countering.
Again, it will be at least a year before we have the data and answers we need. A lot of good research has begun, and preliminary studies are not only helping shape treatment (and response), but are identifying and refining areas of future research and development. May I highly suggest not trusting media reports on the research: it is often flat out (deliberately in some cases) wrong, as I pointed out yesterday. Go to the papers, read the abstract, and on short papers take the time to read the entire publication. It is well worth the time.
I will also say that the continued war on Hydroxychloroquin is disgusting at best. The people behind this, and who actively push it, are doing a tremendous disservice and frankly should be held accountable for it. They would literally, not figuratively, rather people die than to admit that it has been shown to be effective in a number of cases. They continue to ignore as much as possible that an American study, the results of which were presented to the CDC in 2005 (link in previous updates), showed that it was effective against ALL covids. This active bit of stupidity needs to have legal consequences, as well as social.
In conclusion, don’t let the MSM wind you up or be your main source of info. When it comes to false information, they lead the pack.
Since the media isn’t going to say it, once again, COVID-19 is not Capt. Tripps. It is not the flu or a cold. Chill, distance, and use good hygiene. STOP THE PANIC!
Also, a reminder once again: if you are sick or think you are sick, DO NOT GO TO WORK OR TO VISIT PEOPLE. Stay the frack home. Don’t be Stupid, go to work/out, and insist on getting up close and personal to everyone you meet. Yes, Stupid is capitalized as I work with Stupid, who did just that. Don’t be Stupid.
If my posts are enjoyable, helpful, or otherwise a benefit, please consider hitting the tip jar. Any help is very much appreciated, especially as I’ve been off work without pay since 27 Mar.
•My Amazon Wishlist
As always:
If you suspect you have COVID-19 or have been exposed: call your state health department and work with them so that you can be dealt with in a way that minimizes the chance of spreading the virus to those helping you and to the general public. Can’t get them? Call your local department or see if your health service has online/telemedicine screening set up; or see if one who has will let you use it even if you are not in their network. Do not go out in public, and don’t go to an ER or other facility without calling ahead. Be smart.
Use the interactive graphic to keep track of things. Is COVID19 an epidemic? Yes. Is it a Pandemic? Yes. Is there need for panic? NO. HELL NO. Should you be paying attention? Yes. Hell yes. Should you be preparing? Yes, better late than never. And good luck finding/getting stuff.
Want to avoid catching COVID19 here in the U.S.? Wash your flippin hands frequently, wash them thoroughly every time you use the bathroom, then follow with hand sanitizer after every washing, use hand sanitizer liberally when you can’t wash on a regular basis. Cover your mouth and nose when you sneeze, and stay away from those who don’t. Also, keep your bugger hooks out of/away from your eyes, nose, and mouth. Do NOT shake hands with anyone, and avoid touching or being touched by strangers. Or your strange friends.
Avoid travel if at all possible. If you have to travel, or go out for any reason, use lots of hand sanitizer and go to full flu protocols. If you have to use a public restroom, take full precautions including using paper towels and such to handle faucets, doors,etc. Believe it or not, this was highly recommended before now, and major grocery chains have long told employees to use those practices to avoid getting or spreading colds, flu, etc. Not many actually do it, but…
If you own a business, make sure your employees know the above protocols. Have someone who refuses to wash their hands or otherwise follow the protocols? Talk to them, write them up, and if necessary fire them as they now pose a risk of infection to you and your customers. Extreme? Yes, but while the CDC and others are working to slow it down, odds are it is already here and could hit hard and fast. Prepare for the worst and hope for the best.
I want to reiterate that there is no need for panic, but there is a strong need to be alert, be informed, and be prepared.
Good Sources Of Information On COVID-19
Instapundit (no longer doing roundups, but great articles from Glenn and his team)
South China Morning Post (decent, some salt may be needed)
Business Insider (decent, even if they did fall for some lies about Trump)
New England Journal of Medicine
Additional link to Johns Hopkins
More to come
Local Independent Businesses That Need Your Support
Oaken Barrel (Twitter at @OakenBarrel)
More to come
Other COVID19/COVID-19/2019-nCoV articles:
COVID-19 13Mar20 The Game Of Loads And Vectors Gets Real For America
COVID-19 9Mar20 The Game Of Loads And Vectors
COVID-19 7Mar20 How To Do It Right If You Have/Have Been Exposed To COVID-19
Quick Additional Thoughts On The Bureaucracy
COVID-19 28Feb20 Reasons To Hope, Reasons To Fear
COVID-19 A Plea To The Politicians (And Media)
COVID19 The Situation In China Gets Even Weirder
COVID19 24Feb20 Raising DEFCON
COVID19 21Feb20: Just Look At The Blooms Dear
Update & Quick Thoughts On Preparedness
COVID-19 16Apr20
Yes, I took a few days off. First, most of the news on COVID-19, aka Winnie the Flu/Xi Flu/Chinese Flu/etc., was political in nature rather than science based. Second, a lot of the more learned discussion had to do with models, and much of the really good discussions on that would be “inside baseball” to most people. Short version remains, however, that the prime model used for policy is seriously flawed and even with corrections is not yet close to reality. Until it is, it should not be used for policy decisions in my opinion. Third, I needed a break and got some other things done.
Before I get to the main topic for today, two quick notes. It is good to see that what was previously taboo is now going mainstream. Back two months ago, if you talked about the safety problems at both labs in Wuhan and even appeared to entertain the idea it could have been a lab accident, you were guilty of spreading false information and could be deplatformed. I’m glad several of us did, and even more glad to see some more open discussion of those problems and the possibility this started in a lab.
This article asks another taboo question that needs full and honest discussion. Given that the Chinese economy is brittle and was already in trouble; and, that Xi seized the opportunity to expand monitoring even as troublesome people were disappeared and various cleansings expanded, it is not outside the realm of possibility that Xi decided to level the world economic field a bit and make the most of it.
The main topic for today, however, is a study being breathlessly touted in the media for saying it is futile to develop a vaccine (and with some other slams). No, no it does not say that vaccine research is futile. Not unless you selectively edit the quote.
“Based on the close relationship of SARS-CoV-2 to SARS, current vaccine and drug development for SARS-CoV-2 has also focused on the S protein and its human binding receptor ACE2 (7, 24). Thus, the observation in this study raised the alarm that SARS290 CoV-2 mutation with varied epitope profile could arise at any time, which means current vaccine development against SARS-CoV-2 is at great risk of becoming futile. “
Let’s break this down and take on some of the media talking points.
Point 1: Until it is peer reviewed, and other studies confirm (or refute) it’s findings, I don’t trust it. Number of reasons, including that early studies can be like early reporting: full of errors and sensationalism.
Point 2: A finding of the study is that a mutation of COVID-19 has been found in India. That mutation, if you go to line 282 in the paper, actually makes that version less infectious as it reduces the ability to bind to ACE2 receptors. Did you get that? The mutation is less infectious, not more.
Point 3: Unlike some other covids and other viruses, the rate of mutation in COVID-19 is slow. If you go to line 229, this paper confirms that and even goes so far as to note “A relatively stable genome of SARS-CoV-2 is a good indication for the epidemic control, as less mutation raises the hope of the rapid development of validate vaccine and antiviral drugs.” Hardly the breathless gloom and doom implied by various headlines and discussion.
Point 4: Going back to the discussion above, changes in the S protein may make vaccine development targeted to that protein (and the related ACE2 binding) futile. Not all vaccines, just that target.
There are some other interesting points in the paper, but again it has to be taken with caution for now. As other studies replicate or provide information, a better assessment can be made.
As I discussed in a previous update that discussed structure-based drug design, viruses mutate. It’s a given. Some mutate slowly, some like an ADD squirrel in a field of nuts. Some mutations make the virus easier to catch, some make it more deadly, others can change receptors, symptoms, and more.
The fact is, however, that quite a few of those mutations are evolutionary dead-ends. Too deadly, and people die before they can transmit it. Less infectious (as seems to be the case discussed here), again, it is a strain that could die out well before others.
The key to vaccine development for fast mutations is to find targets that don’t change, because when those change that strain dies out. There are always such targets, the trick is finding them and finding ways to target them.
In conclusion, don’t let the MSM wind you up or be your main source of info. When it comes to false information, they lead the pack.
Since the media isn’t going to say it, once again, COVID-19 is not Capt. Tripps. It is not the flu or a cold. Chill, distance, and use good hygiene. STOP THE PANIC!
Also, a reminder once again: if you are sick or think you are sick, DO NOT GO TO WORK OR TO VISIT PEOPLE. Stay the frack home. Don’t be Stupid, go to work/out, and insist on getting up close and personal to everyone you meet. Yes, Stupid is capitalized as I work with Stupid, who did just that. Don’t be Stupid.
If my posts are enjoyable, helpful, or otherwise a benefit, please consider hitting the tip jar. Any help is very much appreciated, especially as I’ve been off work without pay since 27 Mar.
•My Amazon Wishlist
As always:
If you suspect you have COVID-19 or have been exposed: call your state health department and work with them so that you can be dealt with in a way that minimizes the chance of spreading the virus to those helping you and to the general public. Can’t get them? Call your local department or see if your health service has online/telemedicine screening set up; or see if one who has will let you use it even if you are not in their network. Do not go out in public, and don’t go to an ER or other facility without calling ahead. Be smart.
Use the interactive graphic to keep track of things. Is COVID19 an epidemic? Yes. Is it a Pandemic? Yes. Is there need for panic? NO. HELL NO. Should you be paying attention? Yes. Hell yes. Should you be preparing? Yes, better late than never. And good luck finding/getting stuff.
Want to avoid catching COVID19 here in the U.S.? Wash your flippin hands frequently, wash them thoroughly every time you use the bathroom, then follow with hand sanitizer after every washing, use hand sanitizer liberally when you can’t wash on a regular basis. Cover your mouth and nose when you sneeze, and stay away from those who don’t. Also, keep your bugger hooks out of/away from your eyes, nose, and mouth. Do NOT shake hands with anyone, and avoid touching or being touched by strangers. Or your strange friends.
Avoid travel if at all possible. If you have to travel, or go out for any reason, use lots of hand sanitizer and go to full flu protocols. If you have to use a public restroom, take full precautions including using paper towels and such to handle faucets, doors,etc. Believe it or not, this was highly recommended before now, and major grocery chains have long told employees to use those practices to avoid getting or spreading colds, flu, etc. Not many actually do it, but…
If you own a business, make sure your employees know the above protocols. Have someone who refuses to wash their hands or otherwise follow the protocols? Talk to them, write them up, and if necessary fire them as they now pose a risk of infection to you and your customers. Extreme? Yes, but while the CDC and others are working to slow it down, odds are it is already here and could hit hard and fast. Prepare for the worst and hope for the best.
I want to reiterate that there is no need for panic, but there is a strong need to be alert, be informed, and be prepared.
Good Sources Of Information On COVID-19
Instapundit (no longer doing roundups, but great articles from Glenn and his team)
South China Morning Post (decent, some salt may be needed)
Business Insider (decent, even if they did fall for some lies about Trump)
New England Journal of Medicine
Additional link to Johns Hopkins
More to come
Local Independent Businesses That Need Your Support
Oaken Barrel (Twitter at @OakenBarrel)
More to come
Other COVID19/COVID-19/2019-nCoV articles:
COVID-19 13Mar20 The Game Of Loads And Vectors Gets Real For America
COVID-19 9Mar20 The Game Of Loads And Vectors
COVID-19 7Mar20 How To Do It Right If You Have/Have Been Exposed To COVID-19
Quick Additional Thoughts On The Bureaucracy
COVID-19 28Feb20 Reasons To Hope, Reasons To Fear
COVID-19 A Plea To The Politicians (And Media)
COVID19 The Situation In China Gets Even Weirder
COVID19 24Feb20 Raising DEFCON
COVID19 21Feb20: Just Look At The Blooms Dear
Update & Quick Thoughts On Preparedness
COVID-19 10Apr20
A while back, I linked to an article about the CDC shutting down a number of lab tests that were faster and better than their own. This morning, there was secondary confirmation of that story.
When we look back on this event, the initial botched response by the CDC, and the absolute failure of testing coming from the actions of the CDC and FDA, should rightly take center stage. Testing is essential to identify, to develop treatments, and to limit the spread. To this day, the FDA and CDC continue to erect stonewall after stonewall to efforts to that would end this ordeal.
In my book, the failure of testing — and to get us the millions of tests we need both for the disease and for the antibodies — is the single largest failure of the response. With proper testing, you can scale responses to an appropriate degree for the situation, instead of slamming a “one size fits all” approach to the situation. With proper testing, you can clear those who are immune to return to work, along with those who are not a major risk. With proper testing and reporting, you can get critical supplies to where they are needed most, and even get them there ahead of the time of most urgent need.
Yet, bureaucratic roadblocks keep getting raised to effective, efficient, and desperately needed testing. It truly begs a question: Why?
Since the media isn’t going to say it, once again, COVID-19 is not Capt. Tripps. It is not the flu or a cold. Chill, distance, and use good hygiene. STOP THE PANIC!
Also, a reminder once again: if you are sick or think you are sick, DO NOT GO TO WORK OR TO VISIT PEOPLE. Stay the frack home. Don’t be Stupid, go to work/out, and insist on getting up close and personal to everyone you meet. Yes, Stupid is capitalized as I work with Stupid, who did just that. Don’t be Stupid.
If my posts are enjoyable, helpful, or otherwise a benefit, please consider hitting the tip jar. Any help is very much appreciated, especially as I’ve been off work without pay since 27 Mar.
•My Amazon Wishlist
As always:
If you suspect you have COVID-19 or have been exposed: call your state health department and work with them so that you can be dealt with in a way that minimizes the chance of spreading the virus to those helping you and to the general public. Can’t get them? Call your local department or see if your health service has online/telemedicine screening set up; or see if one who has will let you use it even if you are not in their network. Do not go out in public, and don’t go to an ER or other facility without calling ahead. Be smart.
Use the interactive graphic to keep track of things. Is COVID19 an epidemic? Yes. Is it a Pandemic? Yes. Is there need for panic? NO. HELL NO. Should you be paying attention? Yes. Hell yes. Should you be preparing? Yes, better late than never. And good luck finding/getting stuff.
Want to avoid catching COVID19 here in the U.S.? Wash your flippin hands frequently, wash them thoroughly every time you use the bathroom, then follow with hand sanitizer after every washing, use hand sanitizer liberally when you can’t wash on a regular basis. Cover your mouth and nose when you sneeze, and stay away from those who don’t. Also, keep your bugger hooks out of/away from your eyes, nose, and mouth. Do NOT shake hands with anyone, and avoid touching or being touched by strangers. Or your strange friends.
Avoid travel if at all possible. If you have to travel, or go out for any reason, use lots of hand sanitizer and go to full flu protocols. If you have to use a public restroom, take full precautions including using paper towels and such to handle faucets, doors,etc. Believe it or not, this was highly recommended before now, and major grocery chains have long told employees to use those practices to avoid getting or spreading colds, flu, etc. Not many actually do it, but…
If you own a business, make sure your employees know the above protocols. Have someone who refuses to wash their hands or otherwise follow the protocols? Talk to them, write them up, and if necessary fire them as they now pose a risk of infection to you and your customers. Extreme? Yes, but while the CDC and others are working to slow it down, odds are it is already here and could hit hard and fast. Prepare for the worst and hope for the best.
I want to reiterate that there is no need for panic, but there is a strong need to be alert, be informed, and be prepared.
Good Sources Of Information On COVID-19
Instapundit (no longer doing roundups, but great articles from Glenn and his team)
South China Morning Post (decent, some salt may be needed)
Business Insider (decent, even if they did fall for some lies about Trump)
New England Journal of Medicine
Additional link to Johns Hopkins
More to come
Local Independent Businesses That Need Your Support
Oaken Barrel (Twitter at @OakenBarrel)
More to come
Other COVID19/COVID-19/2019-nCoV articles:
COVID-19 13Mar20 The Game Of Loads And Vectors Gets Real For America
COVID-19 9Mar20 The Game Of Loads And Vectors
COVID-19 7Mar20 How To Do It Right If You Have/Have Been Exposed To COVID-19
Quick Additional Thoughts On The Bureaucracy
COVID-19 28Feb20 Reasons To Hope, Reasons To Fear
COVID-19 A Plea To The Politicians (And Media)
COVID19 The Situation In China Gets Even Weirder
COVID19 24Feb20 Raising DEFCON
COVID19 21Feb20: Just Look At The Blooms Dear
Update & Quick Thoughts On Preparedness
COVID-19 9Apr20
Rather than get into all of the sturm un drang of the ongoing wars over data, who is counted as a casualty, and other fun stuff, I’m increasingly reminded of something that happened many years ago with another computer model. It brought home to me that models are only as good as the assumptions and data that go in, and on the competence of the person or persons developing the model.
Back in a galaxy far, far, away — wait, wrong intro. Back in the bad old days of Ronald Maximus Reagan, the left was in full fury (nothing’s changed, has it?) railing against him and his efforts to restore our military. Some scientists did a study, and created a model, showing that a nuclear exchange (which while possible, was not as probable as they made out) would cause a “nuclear winter.” A new, radioactive ice age that would doom the few poor survivors of the exchange. Lot of controversy, lots of distortion of the work, and thankfully lots of push back.
To cut short the timeline a bit, I was talking a few years later with a modeling and simulation expert at Argonne National Labs who worked with their “holo deck” (not the official name, but the highly unofficial one most people used) system. This 3-D imaging system was extremely realistic, and if you were in it on one particular scenario, they reminded you that if you started to feel motion sick, close your eyes — yes, it was that realistic. It was also amusing to watch a group inside it all swaying in unison as it was running…
We got to talking models, and the nuclear winter model came up. Seems that the original model was flawed, to put it mildly. In effect, the original model only had three dimensions (IIRC). The atmosphere was treated as a single mass; the earth was treated as a single mass; and, the nuclear explosions were effectively treated as one event. Not terribly realistic, and not even the weather models of the day were that simplistic.
According to the scientist I was talking with, to start getting realistic results you had to break the atmosphere into (at least) 15 different layers, which means at least 15 more dimensions to the model. By the time that was done and other sections brought up to something approaching reality, nuclear winter became, at worst, nuclear autumn. Not saying a nuclear exchange would be a good thing, but it would not result in the catastrophic weather changes the study touted.
More and more, as we deal with the various models, I’m reminded of the nuclear winter model. When you try to simplify things, or assume that something is simple, you are going to have problems. I wonder what a post-mortem of the models will show, and if this might not be a factor. We will see.
Since the media isn’t going to say it, once again, COVID-19 is not Capt. Tripps. It is not the flu or a cold. Chill, distance, and use good hygiene. STOP THE PANIC!
Also, a reminder once again: if you are sick or think you are sick, DO NOT GO TO WORK OR TO VISIT PEOPLE. Stay the frack home. Don’t be Stupid, go to work/out, and insist on getting up close and personal to everyone you meet. Yes, Stupid is capitalized as I work with Stupid, who did just that. Don’t be Stupid.
If my posts are enjoyable, helpful, or otherwise a benefit, please consider hitting the tip jar. Any help is very much appreciated, especially as I’m now off work without pay.
•My Amazon Wishlist
As always:
If you suspect you have COVID-19 or have been exposed: call your state health department and work with them so that you can be dealt with in a way that minimizes the chance of spreading the virus to those helping you and to the general public. Can’t get them? Call your local department or see if your health service has online/telemedicine screening set up; or see if one who has will let you use it even if you are not in their network. Do not go out in public, and don’t go to an ER or other facility without calling ahead. Be smart.
Use the interactive graphic to keep track of things. Is COVID19 an epidemic? Yes. Is it a Pandemic? Yes. Is there need for panic? NO. HELL NO. Should you be paying attention? Yes. Hell yes. Should you be preparing? Yes, better late than never. And good luck finding/getting stuff.
Want to avoid catching COVID19 here in the U.S.? Wash your flippin hands frequently, wash them thoroughly every time you use the bathroom, then follow with hand sanitizer after every washing, use hand sanitizer liberally when you can’t wash on a regular basis. Cover your mouth and nose when you sneeze, and stay away from those who don’t. Also, keep your bugger hooks out of/away from your eyes, nose, and mouth. Do NOT shake hands with anyone, and avoid touching or being touched by strangers. Or your strange friends.
Avoid travel if at all possible. If you have to travel, or go out for any reason, use lots of hand sanitizer and go to full flu protocols. If you have to use a public restroom, take full precautions including using paper towels and such to handle faucets, doors,etc. Believe it or not, this was highly recommended before now, and major grocery chains have long told employees to use those practices to avoid getting or spreading colds, flu, etc. Not many actually do it, but…
If you own a business, make sure your employees know the above protocols. Have someone who refuses to wash their hands or otherwise follow the protocols? Talk to them, write them up, and if necessary fire them as they now pose a risk of infection to you and your customers. Extreme? Yes, but while the CDC and others are working to slow it down, odds are it is already here and could hit hard and fast. Prepare for the worst and hope for the best.
I want to reiterate that there is no need for panic, but there is a strong need to be alert, be informed, and be prepared.
Good Sources Of Information On COVID-19
Instapundit (no longer doing roundups, but great articles from Glenn and his team)
South China Morning Post (decent, some salt may be needed)
Business Insider (decent, even if they did fall for some lies about Trump)
New England Journal of Medicine
Additional link to Johns Hopkins
More to come
Local Independent Businesses That Need Your Support
Oaken Barrel (Twitter at @OakenBarrel)
More to come
Other COVID19/COVID-19/2019-nCoV articles:
COVID-19 13Mar20 The Game Of Loads And Vectors Gets Real For America
COVID-19 9Mar20 The Game Of Loads And Vectors
COVID-19 7Mar20 How To Do It Right If You Have/Have Been Exposed To COVID-19
Quick Additional Thoughts On The Bureaucracy
COVID-19 28Feb20 Reasons To Hope, Reasons To Fear
COVID-19 A Plea To The Politicians (And Media)
COVID19 The Situation In China Gets Even Weirder
COVID19 24Feb20 Raising DEFCON
COVID19 21Feb20: Just Look At The Blooms Dear
Update & Quick Thoughts On Preparedness